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KMID : 0613820080180020279
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Journal of Life Science
2008 Volume.18 No. 2 p.279 ~ p.283
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Perianal Adenocarcinoma in Dog
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Yang Hai-Jie
Park Ho-Yong
You Sung-Eun
Jeong Kyu-Shik
Do Sun-Hee
Yuan Dong-Wei
Hong Il-Hwa
Ki Mi-Ran
Park Jin-Kyu
Ku Moon-Jung
Lee Hye-Rim
Hwang Ok-Kyung
Han Jung-Youn
Hong Kyung-Sook
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Abstract
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A 12.6-year-old, male Shitzu was diagnosed with perianal adenocarcinoma. The presented mass was brown to black, in size, and yellowish on cut section. Microscopic findings revealed that the mass composed of variable sized clusters of hepatoid cells with inconspicuous distinct. The tumor cells were polyhedral and pyknotic and exhibited high mitotic activity. Tumor cells intermingled with basaloid cells and primitive cells invaded the adjacent normal tissues. Basaloid cells exhibited positive immunoreactivity for Epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER-2/neu), matrix metallopnateinase 9 (MMP-9), and perianal adenocarcinoma, protein kinase C alpha (PKC ). Generally, tumors of the perianal gland are common and benign 4.5 times more often than carcinoma in the dog, particularly in males. In the present report, we examined histopathological and immunohistochemical characteristics of a rare perianal adenocarcinoma in association with proteins involved tumor metastasis and adenocarcinoma development.
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KEYWORD
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Epidermal growth factor receptor, human epidermal growth factor receptor, metastasis, matrix metallopnateinase 9, perianal adenocarcinoma, protein kinase C alpha
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